Polynucleotide encoding a polypeptide having a single n-terminal kringle domain homologous to human plasminogen kringle domain, a c-terminal domain activation site and serine protease domain homologous to corresponding domains in human plasminogen, polypeptide encoded thereby, vector and cell comprising same and method for making said polypeptide

摘要

Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, combined such that no foreign sequences are present, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.