PRODUCTION OF RIFAMYCIN B ANALOG 24-DESMETHYLRIFAMYCIN B BY SWAPPING ACYL TRANSFERASE OF MODULE 6 (PROPIONATE SPECIFIC ) DOMAIN OF RIFAMYCIN POLYKETIDE SYNTHASE (PKS) GENE CLUSTER OF AMYCOTATOPSIS MEDITERRANEI S699 WITH THAT ACYL TRANSFERASE OF MODULE 2 (ACETATE SPECIFIC) DOMAIN OF RAPAMYCIN PKS GENE CLUSTER

摘要

The invention relates to the production of rifamycin analogs against drug resistant bacteria. The invention also relates to antibacterial compounds against drug resistant mycobacteria. The invention also provides for pharmaceutical composition comprising antibacterial compound against drug resistant bacteria, particularly mycobacteria. The invention also provides for use of antibacterial compounds for the treatment of disease caused by bacteria and in particular mycobacteria.