Superparamagnetic iron oxide nanoparticle formulation as mri negative contrast enhancing agent for cancer detection of organs of the reticuloendothelial system and process of its preparation thereof

摘要

A contrast enhancing agent formulation for use in Magnetic Resonance Imaging (MRI) comprising metal oxide nanoparticles encapsulated within a stabilizing coating of a biopolymer chemically conjugated to a targeting ligands specific for reticuloendothelial system (RES) organs, process of its preparation and use for accurate and efficient detection of cancer of liver and similar organs.