NANODRUG DELIVERY BASED ON COMBINATION THERAPY FOR TREATING PARASITE INFECTIONS

摘要

The present invention relates to novel nanodrug delivery system, with the targeted approaches for treating infectious diseases using combination of more than one pharmaceutical active ingredients formulated as single unit dosage form. The invention further relates to combining actives with potent activity, completely vivid host target sites and distinct kinetic profiles with the aim of improving delivery of these pharmaceutical active ingredients. More particularly the developed novel nanodrug delivery system involves engineered nanostructured carriers of lipophilic active drugs like antimalarial agent along with a hydrophilic class of antibiotics. The invention thus relates to development of nano coformulation preconcentrate based on combination therapy for treating infections ranging from uncomplicated as well as severe malaria to cerebral malaria.