Method for producing pemetrexed disodium salt in high purity amorphous form and the crystalline forms of N-4-(2-(-amino-4,7-dihydro-4-oxo-3H-pyrrolo2,3-dpyrimidin-5-yl)ethylbenzoyl-L-glutamic acid

摘要

method of manufacturing amorphous form of pemetrexed disodium salt in high purity is characterized by the fact that acid, n - [4 - [2 - (2 - amino - 4.7 - dihydro - 4 - oxo - 3h pyrrolo [2,3-d] pyrimidin-5-yl) ethyl] benzoyl] - l-glutamic acid is subjected to reaction at water free conditions with niedomiarem molar relationship producing sodium ions in relation to free acid carboxyl groups.in the positive uses acid n - [4 - [2 - (2 - amino - 4.7 - dihydro - 4 - oxo - 3h pyrrolo [2,3-d] pyrimidin-5-yl) ethyl] benzoyl] - l-glutamic acid in a new crystalline form 1 or 2, the content of from 27 to 31% dimetylosulfotlenku of pemetrexed disodium salt.