Protein binding domains of the protein family of repulsive targeting molecules (RGM) and functional fragments thereof, as well as their use

摘要

Neogenin receptor binding domain of the repulsive targeting molecule (RGM) with an amino acid sequence of amino acid position 200 to 350 according to SEQ ID NO: 2, amino acid position 200 to 325 according to SEQ ID NO: 2 , or from amino acid position 200 to 300 according to SEQ ID NO: 2, or from amino acid position 200 to 285 according to SEQ ID NO: 2, or from amino acid position 250 to 285 according to SEQ ID NO: 2, or of amino acid position 260 to 285 according to SEQ ID NO: 2, or amino acid position 215 to 340 according to SEQ ID NO: 2, or amino acid position 260 to 340 according to SEQ ID NO: 2, or of the amino acid position 250 to 300 according to SEQ ID NO: 2, or amino acid position 260 to 291 according to SEQ ID NO: 2, or amino acid position 210 to 260 according to SEQ ID NO: 2, or the position of amino acids 290 to 350 according to SEQ ID NO: 2, or a functional neogenin receptor binding fragment thereof with a length d and 10-30 consecutive amino acid residues, or equivalent to the functional neogenin receptor binding thereof with a sequence homology of at least 75%.