CERS5 AS A PREDICTIVE VARIABLE OF RESPONSE TO CANCER THERAPY AND IN PARTICULAR NEOADJUVANT CANCER THERAPY

摘要

A method of predicting the likelihood of a patient with a solid tumor cancer or a metastasis thereof responding to cancer therapy comprises the steps of assaying a sample of the primary solid tumor or a local or distant metastasis thereof obtained from the patient to determine a level of expression of CerS5, and if an elevated CerS5 expression level is detected in the sample from the patient, then predicting a likelihood that the patient will have a positive clinical response to cancer therapy, or if a non-elevated CerS5 expression level is detected in the sample from the patient, then predicting a likelihood that the patient will have a negative clinical response to cancer therapy.