RADIATION EXPOSURE DIAGNOSTIC MARKER IGFBP-5, COMPOSITION FOR RADIATION EXPOSURE DIAGNOSIS BY MEASURING THE EXPRESSION LEVEL OF THE MARKER, RADIATION EXPOSURE DIAGNOSTIC KIT COMPRISING THE COMPOSITION, AND METHOD FOR DIAGNOSING RADIATION EXPOSURE USING THE MARKER

摘要

The present invention provides: a composition for radiation exposure diagnosis including an agent for measuring an expression level of an insulin-like growth factor-binding protein-5 (IGFBP-5) gene at an mRNA or the protein; a kit for radiation exposure diagnosis including the composition; a method of diagnosing radiation exposure by measuring the expression level of the IGFBP-5 gene at an mRNA or the protein in a patient's sample; a method of screening an agent for enhancing radiation sensitivity by selecting a sample having increased expression levels of the IGFBP-5 gene at an mRNA or the protein compared to those of a control group; a method of screening an agent for radiation protection by selecting a sample having decreased expression levels of the IGFBP-5 gene at an mRNA or the protein compared to those of a control group; a composition for enhancing radiation sensitivity including an agonist to expression or action of the IGFBP-5 gene at an mRNA or the protein; and a composition for radiation protection including an antagonist to expression or action of the IGFBP-5 gene at an mRNA or the protein.