MITOCHONDRIAL DNA COPY NUMBER AS A PREDICTOR OF FRAILTY, CARDIOVASCULAR DISEASE, DIABETES, AND ALL-CAUSE MORTALITY

摘要

The present invention provides methods and compositions related to the use of mitochondrial DNA copy number as a predictor of frailty, cardiovascular disease, diabetes and all-cause mortality. In one embodiment, a method for predicting cardiovascular disease in a subject comprises the steps of (a) obtaining a biological sample from the subject; (b) performing an assay to measure the mitochondrial DNA (mtDNA) copy number in the biological sample; and (c) identifying the subject as likely to develop cardiovascular disease by comparison of the mitochondrial DNA copy number to a control.