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Synthesis of chromane compounds and their derivatives by a copper-catalyzed conjugate addition reaction
Synthesis of chromane compounds and their derivatives by a copper-catalyzed conjugate addition reaction
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机译:铜催化共轭加成反应合成苯并二氢吡喃及其衍生物
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摘要
The present invention relates to the preparation of chromane compounds and their derivatives by a copper-catalyzed conjugate addition reaction. It has been observed that in highly stereoselective manner a methyl group can be introduced to the 2 position of chromane ring by reaction of a chromenone with Al(CH3)3 in the presence of a Cu(I) salt and specific chiral phosphoramidites. The compounds obtained are important intermediates particularly for the synthesis of chiral tocopherols.
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