RAB1A GENE POLYMORPHISMS IN AERD AND BIOMARKER AND KIT FOR DIAGNOSISING AND DISTINGUSHING AERD INCLUDING RAB1A GENE

摘要

The present invention relates to a marker composition including RAB1A genes for aspirin-exacerbated respiratory diseases (AERD) and a diagnostic kit thereof. More specifically, the AERD diagnosis marker includes the single nucleotide polymorphisms (SNPs) of the RAB1A genes used as a marker for revealing the progression of AERD. The present invention investigates the relationship between the single nucleotide polymorphisms of the RAB1A genes and the AERD. In a logistic regression analysis, the minor allele frequency of +41170 CGon at intron 5 is confirmed to be significantly lower in the AERD group (n = 261) than in the ATA group (n = 1016). In a linear regression analysis, a strong relationship between the +41170 CG and the FEV1 decrease in the aspirin resistance is confirmed to exist (P= 0.01). The RAB1A genes can be crucial to the improvement of the asthmatic patient. The genetic polymorphism of the genes potentially can be used as a marker for the diseases.