METHOD FOR PREPARING LIPOSOME PREPARATION CONTAINING AMPHOTERICIN B WITH INCREASED ENTRAPMENT EFFICIENCY AND IMPROVED STORAGE STABILITY, AND LIPOSOME PREPARATION OBTAINED THEREFROM

摘要

The present invention relates to a method for preparing a liposome preparation containing amphotericin B, and a liposome preparation containing amphotericin B prepared thereby. According to the preparation method of the present invention, provided is a liposome preparation containing amphotericin B, in which free amphotericin B that is not enclosed in the liposome is maintained at a content of less than 1%, and amphotericin B is stably enclosed in the liposome, thereby reducing cytotoxicity to normal cells, increasing enclosing efficiency to improve productivity, and controlling the grain particle distribution to improve storage stability.