PPAR- Composition comprising inhibitors of neddylation of PPAR-for preventing adipogenesis and its use

摘要

The present invention discloses a pharmaceutical composition for inhibiting adipocyte differentiation comprising an adenylation inhibitor of PPAR-v and a method for screening adipocyte differentiation inhibitors using the nudeylation of the present PPAR-v associated with adipocyte differentiation. The composition according to the present invention is a new concept of adipocyte differentiation inhibitor based on the relationship between the neuralization of PPAR-v and adipocyte differentiation, and can be effectively used for the treatment of obesity by inhibiting differentiation from mesenchymal stem cells into mast cells In particular, it can be used for treatment of obesity, which is not expected to be effective as a conventional treatment for obesity.