METHOD qualitative and quantitative morphological diagnosis pathological ZHELEZODEKSTRANA INFLUENCE ON THE STATE OF THE LIVER OF PIGS

摘要

A method of qualitative and quantitative morphological diagnosis of having the pathological effect zhelezodekstrana on the liver of pigs after administration at a dose of 2 ml per animal, comprising carrying out the morphological systemic sequential analysis of histological sections of the liver with the description of histological structure of the liver as well as the measurement of the average number of binuclear hepatocytes apoptotic cells cells and the mononuclear macrophage system using a light microscope in 30 consecutive fields of view at total magnification of 100x, the identification complex pathognomonic morphological changes including the presence of blood filling sinusoidal capillaries, edema of Disse space swelling vascular endothelium, granular dystrophy hepatocytes, increasing the average number of cells the mononuclear macrophage system, including hemosiderophages 2 times or more (KC × 2), as well as increasing the number of binucleated hepatocytes (BH × 2) and apoptotic bodies 2 times or more (AB × 2).