METHOD FOR EVALUATING RISK OF DUODENAL ULCER IN KHAKASS BY GENETIC ANALYSIS

摘要

FIELD: medicine.;SUBSTANCE: risk factors are specified - IL-8 interleukin polymorphism is determined by restriction analysis with recovering DNA from venous blood lymphocytes; Helicobacter pylori is genetically typed by PCR with recovering DNA from gastric mucosa biopsy material in the patients being native inhabitants of the Republic of Khakassia. The risk factors are assigned with numerical values, and prognostic coefficients P1, P2 are determined. If P1P2 a lower risk is predicted, whereas P1P2 shows a high risk of peptic ulcer disease. The presented method possesses a high prognostic significance of the positive result in evaluating the risk of duodenal ulcer in Khakass (89.7%).;EFFECT: more accurate evaluation of the risk of duodenal ulcer by genetic analysis at the stage of pre-clinical manifestations, for the purpose of taking effective measures aiming at prevention this common disease.;2 ex