USE OF RECOMBINANT CALRETICULIN OF TAENIA SOLIUM IN ORDER TO INDUCE THE EXPRESSION OF INTERLEUKIN 10

摘要

The present invention is related to the use of a recombinant protein to induce interleukin 10 expression, wherein the protein is Taenia solium parasite recombinant calreticulin (rTsCRT) formulated in a physiologic glycosated solution orally or parenterally administered. The used methodology for rTsCRT expression and purification described in present invention, resulted in a recombinant protein expressed without post-translational modifications having regulatory immunological effects and capable of stimulating the mRNA transcription levels which codify for IL-4 and IL-10 cytokines. rTsCRT expression is conducted in an E. coli untagged system, though applicable to any expression system, whether prokaryote or eukaryote cells. The purpose of producing rTsCRT is to use it for treatment of local or systemic inflammatory diseases.