ANTI-Aβ GLOBULOMER ANTIBODIES, ANTIGEN-BINDING MOIETIES THEREOF, CORRESPONDING HYBRIDOMAS, NUCLEIC ACIDS, VECTORS, HOST CELLS, METHODS OF PRODUCING SAID ANTIBODIES, COMPOSITIONS COMPRISING SAID ANTIBODIES, USES OF SAID ANTIBODIES AND METHODS OF USING SAID ANTIBODIES

摘要

PROBLEM TO BE SOLVED: To provide anti-Aβ globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing the antibodies, compositions comprising the antibodies, uses of the antibodies and methods of using the antibodies.SOLUTION: The present invention relates to anti-Aβ globulomer antibodies having a binding affinity to Aβ(20-42) globulomer that is greater than the binding affinity of the antibody to Aβ(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing the antibodies, nucleic acids encoding the antibodies, vectors comprising the nucleic acids, host cells comprising the vectors, methods of producing the antibodies, compositions comprising the antibodies, therapeutic and diagnostic uses of the antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses.SELECTED DRAWING: None