Multiple myeloma, chronic lymphocytic leukemia, and improved diagnostic methods of B-cell non-Hodgkin's lymphoma, prognosis prediction method, and monitoring methods

摘要

P- present invention provides a method of diagnosing multiple myeloma (MM). In certain embodiments, a method of diagnosing the MM is, BCMA polypeptide detected in (a) detecting the amount of BCMA polypeptide or fragment thereof in a biological sample obtained from the subject, (b) step (a) the amount of the peptide or fragment thereof, comprising the steps of: comparing the amount detected in a predetermined cutoff value or control serum samples were compared to the amount of control serum samples of predetermined cutoff value or (b) increased amount of BCMA polypeptide or fragment in a biological sample of (a) comprises the steps of indicating the presence of MM, the biological sample is a serum sample or a subject of bone marrow mononuclear cells or peripheral blood mononuclear cells, it is a supernatant obtained from the culture.