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Mutations in the LNK gene in patients with myeloproliferative neoplasms and other hematological malignancies
Mutations in the LNK gene in patients with myeloproliferative neoplasms and other hematological malignancies
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机译:骨髓增生性肿瘤和其他血液系统恶性肿瘤患者LNK基因的突变
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摘要
Aspects of the present invention include methods, compositions and kits for classifying a subject as having or being predisposed to a hematolymphoid neoplasm or malignancy if they harbor a mutation in the LNK gene. Aspects of the present invention also include screening for candidate agents for treating LNK mutation-based hematolymphoid neoplasms or malignancies in cell-based and cell free assays as well as therapeutic compositions for treating a LNK-mutant based hematolymphoid disorder. Also provided are compositions, systems, kits and computer program products that find use in practicing the subject methods.
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