Amphiphilic block copolymer, method for preparing the same, and micellar drug encapsulation system formed of the copolymer and an antitumor agent

摘要

The present invention relates to a novel amphiphilic block copolymer, a method for preparing the same, and a micellar drug encapsulation system formed of the copolymer and an antitumor drug. The amphiphilic block copolymer includes a hydrophilic segment and a hydrophobic segment, and the end group of the hydrophobic segment is end-capped with a hydrophobic group. A methoxypolyethylene glycol (or polyethylene glycol) -polyester block copolymer that has been recognized as safe is used as a basic material of the amphiphilic block copolymer of the present invention, and the terminal hydroxyl group of the polyester segment is modified with a hydrophobic group. Therefore, the compatibility between the drug molecule and the hydrophobic segment of the block copolymer is improved, and the interaction therebetween is enhanced. In addition, a larger space is provided for accommodating drug molecules. The micelle has a higher effect of regulating drug molecules inside the micelle core and prevents the drug from dissolving out of the micelle. Therefore, highly stable drug-encapsulated micelles can be obtained.