How to test method to normalize the measured drug concentration, and the possibility of non-compliance with drug treatment plan

摘要

Method for monitoring compliance with the target of prescribed treatment plan is disclosed. In one embodiment, the method includes measuring drug levels in the body fluid of a subject, and to normalize as a function of one or more parameters associated with the measured drug levels in the subject. This drug levels can be normalized using a secondary quantile regression. Embodiments of the present method can use both primary metabolites and secondary metabolites in normalization, may allow a change in the dispersion by dose, to allow asymmetrical in the upper and lower variance of predicted median obtained, and / or, for example, percentile for -1 standard deviation, 0 percentile to the standard deviation, and using the analysis variable containing a stable forecast of variables, and the like related to the percentile for the +1 standard deviation.FIELD 3