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Translational construction and search for active species of special peptide compound library containing N-methylamino acid and other special amino acids
Translational construction and search for active species of special peptide compound library containing N-methylamino acid and other special amino acids
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机译:含有N-甲基氨基酸和其他特殊氨基酸的特殊肽化合物文库的翻译构建及活性种的寻找
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摘要
A method for screening a non-standard peptide compound in the peptide library that binds to the target substance, comprising the steps: (i) preparing a non-standard peptide library wherein a special (non-standard) amino acid is randomly incorporated into the peptide sequence by a cell-free ( in vitro ) translation system comprising a tRNA acylated by a special (non-standard) amino acid; (ii) bringing the obtained peptide library in contact with a target substance; and (iii) selecting a non-standard peptide that binds to the target substance as an active peptide.
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