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Transgenic reporter system reveals alternative splicing expression profiles and regulatory mechanisms in mammalian organisms
Transgenic reporter system reveals alternative splicing expression profiles and regulatory mechanisms in mammalian organisms
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机译:转基因报告系统揭示了哺乳动物生物体中的可变剪接表达谱和调控机制
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摘要
An object of the present invention is to develop a new alternative splicing reporter system and to provide a method for detecting alternative splicing patterns in a mammalian multicellular organism more precisely, a method for identifying efficiently substances and gene regions that affect alternative splicing in a mammalian multicellular organism, and the like by utilizing the alternative splicing reporter system. Specifically, the present invention relates to a method for detecting alternative splicing in a mammalian multicellular organism, and a method for identifying substances and gene regions that affect alternative splicing in a mammalian multicellular organism, which use a DNA construct in which at least two different reporter genes are inserted into a specific gene that undergoes alternative splicing, or a combination of DNA constructs (a combination of at least two different DNA constructs) in which DNA construct a reporter gene is inserted into a specific gene that undergoes alternative splicing.
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