SPECTRAL FRACTIONATION DETECTION OF GOLD NANOROD CONTRAST AGENTS USING OPTICAL COHERENCE TOMOGRAPHY

摘要

Methods and systems for detecting a gold nanorod (GNR) contrast agent in an optical coherence tomography (OCT) image of a sample are disclosed. In one example approach, a method comprises separating the OCT image at the location into short and long wavelength halves around a center wavelength of the OCT system, calculating a ratio between the short and long wavelength halves, and indicating a gold nanorod contrast agent at the location based on the ratio. In some examples, spectral fractionation may be employed to further divide the short and long wavelength halves into sub-bands to increase spectral contrast, reduce noise, and increase accuracy in detecting GNR in a sample.