Methods for Diagnosing Onset and Monitoring Progression of Huntington's Disease

摘要

The present invention relates to methods of diagnosing onset, monitoring progression and initiating therapies for a neurological disorder, such as juvenile- or adult-onset Huntington's disease, by comparing the levels of one or more plasma and/or cerebrospinal fluid biomarkers. The invention further relates to N-methyl proline, beta-tocopherol, cortisone, pyruvate, phosphate, and trans-4-hydroxyproline as plasma and/or cerebrospinal fluid biomarkers of onset and progression of a neurological disorder, such as Huntington's disease.