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Benzalkonium chloride compositions for inhibiting the hydrolytic activity of endogenous matrix metalloproteinases in dental restorations
Benzalkonium chloride compositions for inhibiting the hydrolytic activity of endogenous matrix metalloproteinases in dental restorations
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机译:苯扎氯铵组合物用于抑制牙齿修复物中内源性基质金属蛋白酶的水解活性
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摘要
The present application relates to dental adhesive and restoration compositions comprising benzalkonium chloride, having the general structure C6H5CH2N(CH3)2—R—Cl, and salts thereof in a range between approximately 0.01% and approximately 10% by weight in dental primer, dental adhesive, dental resin, and other dental polymeric compositions or in dental solutions. In particular, it has been shown that dental compositions comprising benzalkonium chloride result in the inhibition of the hydrolytic activity of MMP on the dentin adhesive layer, thereby reducing the degradation of bond strength between a resulting dental restoration and the underlying dental tissue.
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