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Magnetic resonance imaging contrast agents comprising zinc-containing magnetic metal oxide nanoparticles
Magnetic resonance imaging contrast agents comprising zinc-containing magnetic metal oxide nanoparticles
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机译:包含含锌的磁性金属氧化物纳米粒子的磁共振成像造影剂
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摘要
The present invention relates to an MRI contrast agent that includes zinc-containing water-soluble metal oxide nanoparticles and has an improved contrast effect. The zinc-containing water-soluble metal oxide nanoparticles are characterized by addition of zinc to a matrix comprising the metal oxide nanoparticles or by substitution of metal in the matrix, resulting in the improved contrast effect of MRI. In addition, the zinc-containing metal oxide nanoparticles of the present invention include the MRI contrast agent t having hybrid structures of “zinc-containing metal oxide nanoparticle—biologically/chemically active material” in which the nanoparticle is conjugated with a bioactive material such as proteins, antibodies, and chemical materials.
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