首页>
外国专利>
Predictive marker of DNMT1 inhibitor therapeutic efficacy and methods of using the marker
Predictive marker of DNMT1 inhibitor therapeutic efficacy and methods of using the marker
展开▼
机译:DNMT1抑制剂疗效的预测标志物和使用该标志物的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Provided herein are methods for predicting efficacy of a DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibitor treatment in a subject having a cancer, methods of identifying a subject having a cancer that is more likely to respond to a DNMT1 inhibitor treatment, and methods of selecting a treatment for a subject having a cancer that include determining a level of SOX9 in a sample containing cells from a subject having a cancer. Also provided are methods of treating a subject having a cancer that include selectively administering a DNMT1 inhibitor to a subject having cancer determined to have an elevated level of SOX9 in a sample containing cells from the subject compared to a reference level. Also provided are antibodies and antigen-binding antibody fragments that specifically bind to SOX9, and nucleic acid sequences that contain at least 10 nucleotides complementary to a contiguous sequence present in a SOX9 nucleic acid for use in these methods.
展开▼