Derivatives of N - arilmetilo sulfonamide as negative modulators of NR2A

摘要

Compounds that selectively modulate NMDA receptors containing an NR2A subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the compounds are described. Claim 1: A compound of formula (1) or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer or stereoisomer thereof where: A, B, C and D are independently CR or N provided that at least one A, B, C or D is N; each R is independently selected from the group consisting of H, halogen, C₁₋₅-alkyl,haloalkyl C₁₋₅,CN and O-alkyl; or when both A and B are CR, the R groups in A and B can form, with A and B, a 5,6 or 6,6 bicyclic aryl group or heteroaryl group; R¹ is aryl or heteroaryl both are optionally substituted with one or more substituents which are selected from the group consisting of halogen, C₁₋₅ alkyl,alquilo -C (O) Chaloalkyl, CN, O-aryl, O-alkyl, aryl, and heteroaryl; or R¹ is selected from the group consisting of optionally substituted alkyl, optionally substituted cycloalkyl, or optionally substituted heterocycloalkyl; R² and R² are independently selected from the group consisting of H, and C₁₋₅ alkyl;O r 2 and R 2 can form a bicycle with the carbon they are connected to; X is equal to or equal to C;And selected from group H, lessor c83318325;And a group - A,P¹ is selected from the group consisting of H, and C₁₋₅ alkyl;P² is alkyl O (C₁₋₅) optionally substituted with one or more hydroxy and / or alkoxy groups; or P² is selected from the group consisting of OC (O) R⁴,OC (O) OROC (O) NHROC (O) NR ROC (O) -alquilo-NR Ry O (PO) OOr P1 and P2,they form a cycloalkyl or a heterocycle; R⁴ and R⁵ are independently selected from the group consisting of H, and C₁₋₅ alkyl with the proviso that when P² is OC (O) OR⁴,R830808 is not hydrogen, R3 is - l1-ar1,L¹-N (C₁₋₆ alkyl) ₂,Or other formula (2);1 l83216c83318325 is a linear or separable tar replaced by - Oh, tar - oc832183316c8332625;it is life.Z selected from lease group H and c.83218c833183258t;Or Z and R3,with the nitrogen to which they are connected they can form a heterocycle; Ar¹ is aryl optionally substituted with one or more substituents selected from the group consisting of C₁₋₅ alkyl,Halogen, halogen c83217c83183226,n. And o-rent; or AR1 is an optional heterosexual, replaced by one or more alternatives selected from the c833213125 rental group;Halogen, halogen c83217c83183226,1 Two, two, three, three