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Method of production of antibody, method of production of antibodies, humanized antibody and pharmaceutical composition using a
Method of production of antibody, method of production of antibodies, humanized antibody and pharmaceutical composition using a
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机译:抗体的生产方法,抗体的生产方法,人源化抗体和使用
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摘要
The current invention is directed to the velocity factor. Based on the velocity factor antibodies can be classified, i.e. antibodies can be characterized on their binding properties as e.g. entropic or enthalpic antigen binder. A velocity factor based classification does not require detailed thermodynamic determinations and/or calculations. The velocity factor is the ratio of the antigen-antibody complex association rate constants ka determined at 37° C. and 13° C. As only two experimental determinations are required to calculate the velocity factor this is a fast and high-throughput suited method.
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