truncated l1 hpv52 protein or variant thereof, isolated nucleic acid, vector, host cell, hpv52 viral type particle, composition, pharmaceutical composition or vaccine, method for obtaining a truncated l1 hpv52 protein, method for preparing the hpv52 viral type particle, method for preparing a vaccine, method for preventing hpv infection or a disease caused by hpv infection and use of truncated or variant l1 hpv52 protein

摘要

Provided is a truncated L1 protein of Human Papillomavirus (HPV) Type 52 which, compared to a wild type HPV52 L1 protein, is truncated by 27-42 amino acids at the N-terminal. Also provided are a coding sequence of the truncated HPV52 L1 protein, a virus-like particle (VLP) comprising the protein, and a method of preparing the protein and the VLP using an E. coli expression system. The truncated HPV52 L1 protein and an assembled VLP can be used to prevent an HPV52 infection and a disease caused by HPV52 infection, such as cervical cancer.