compound, composition, methods for modulating an immune response, for treating and / or preventing disease, for modulating cell uptake and / or clearance, or a portion thereof, for modulating antigen recognition, processing and / or presentation material derived from cells or portions thereof to diagnose, predict and / or monitor the state of a disease, to distinguish between a necrotic cell or dead cell to enrich dendritic cells, or a subset thereof or precursor thereof , and for detecting a cell, uses of the compound and / or composition, dentitic cells or precursor thereof and a polypeptide, compound and composition, vector polynucleotide, host cell, population, and kit

摘要

The present invention relates to the identification of proteins which bind the dendritic cell marker known as Clec9A. The present invention provides new compounds for targeting therapeutic agents such as antigens to dendritic cells. Also provided are methods of modulating a humoral and/or T cell mediated immune response to the antigen, methods of delivery of a cytotoxic agent to dendritic cells thereof involved in diseased states, methods of modulating the uptake and/or clearance of cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof, and methods of modulating antigen recognition, processing and/or presentation, as well as immune responses to material derived from cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof.