Crystalline forms of (R)-4-4-(dimethylamino)-1-(4'-fluorophenyl)-hydroxybutyl-3-(hydroxymethyl)-benzonitrile free base and (S)-4-4-(dimethylamino)-1-(4'-fluoro-phenyl)-hydroxybutyl-3-(hydroxymethyl)-benzonitrile free base and of racemic 4-4-(dimethylamino)-1-(4'-fluorophenyl)-hydroxybutyl-3-(hydroxyl-methyl)-benzonitrile toluene hemisolvate

摘要

The present invention relates to processes for manufacture of escitalopram comprising crystallization of the free base forms of the intermediates of (R)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile, (S)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)- hydroxy-butyl]-3-(hydroxymethyl)-benzonitrile and racemic 4-[4-(dimethylamino)-1-(4'-fluoro-phenyl)-hydroxybutyl]-3 (hydroxyl-methyl)-benzonitrile toluene hemisolvate. The present invention also relates to escitalopram and pharmaceutically acceptable salts thereof ob-tained from said processes.