A DEVICE FOR LOCAL INTRA-CORONARY DELIVERY OF 17-BETA ESTRADIOL AND COMPOSITION COMPRISING 17-BETA ESTRADIOL FOR TREATING VASCULAR INJURY

摘要

The cardioprotective effects of estrogen are well recognized. In in vitro experiments, and upon systemic administration, 17-beta estradiol has shown to inhibit vascular smooth muscle cell proliferation and intima hyperplasia and to improve vascular endothelium function, after vascular injury. We hypothesized that locally delivered 17-beta estradiol could prevent restenosis. Compositions are use of 17-beta estradiol for in-situ administration at a vascular injured site are objects of the present invention.