Improved process for the preparation of d-threoritalinic acid hydrochloride by resolution of threo-ritalinic acid using chiral carboxylic acid

摘要

ABSTRACT IMPROVED PROCESS FOR THE PREPARATION OF d-threo-RiTAlAmC ACJt) HYDROCHLORIDE BY RESOLUTION OF dl^threo-mjAHMC ACID USING CHIRAL CARBOXYLIC ACID The invention disclosed in this application relates to an improved process for the manufacture of (/-//ireo-ritalinic acid hydrochloride and l-threo-ntalinic acid hydrochloride in an optically pure form by the resolution of (//-threo-ritalinic acid using a chirai carboxyHc acid. The rf-//ireo-ritalinic acid hydrochloride prepared by the process of the present invention on esterification gives J-Z/rreo-methylphenidate, a very well known CNS stimulant.