CHARACTERIZATION OF POTENTIAL ANTIDIABETIC COMPOUND FROM PADINA BOERGESEN II ALLENDER AND KRAFT AND KRAFT AND ITS EFFECT ON STREPTOZOTOCIN INDUCED DIABETIC RATS

摘要

ABSTRACT OF THE INVENTION Diabetes is a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. According to the International Diabetic Federation, there are more than 371 million people worldwide suffering from diabetes in 2012 and this number is likely to rise even to 552 million by 2030. Seaweeds identified as rich sources of structurally diverse bioactive compounds with great pharmaceutical and biomedical potential in particular, antidiabetic activity. Hence, the present study was carried out to isolate the antidiabetic compound from aqueous extract of Padina boergesenii. Column chromatography and Thin layer column chromatography for the separation of active constituents; Fourier transforms infrared (FTIR) spectroscopy for analysis of the phytoconstituents functional groups; identification of the structure of the active constituents by Nuclear Magnetic Resonance (NMR) spectroscopy: two dimensional nuclear magnetic resonance (2D NMR) spectroscopy for resolving and identifying the nature of chemical sites in the sample; !H - !H COSY (Homonuclear Correlation Spectroscopy) for revealing correlations between coupled protons; the overall analysis indicating a structure of the active constituent of the said extract with a molecular formula = C8Hi603, Molecular weight: 160.21 Da and the Compound name: 3-Hydroxy Octanoic acid.