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A COMPOSITION OF SUBLINGUAL IMMUNOTHERAPY TABLETS WITH DIFFERENT ALLERGENS AND THE METHOD FOR PREPARATION THEREOF
A COMPOSITION OF SUBLINGUAL IMMUNOTHERAPY TABLETS WITH DIFFERENT ALLERGENS AND THE METHOD FOR PREPARATION THEREOF
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机译:含不同过敏原的舌下免疫治疗片的组成及其制备方法
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[0059] Abstract [0060] This invention discloses a composition of sublingual tablets comprising purified extract of either aeroallergen or pollens or insects or fungus or house dust mite or food allergen. In addition, different excipients like diluent, disinteg rant, lubricant, sweetening agent, flavoring agent, glidant and binder are used in a specific proportions to improve the efficacy and physical properties of the tablet. The invention also discloses a method of tablet preparation, which includes preparing slurry of granulating ag ents and mixing slurry with intragranular agents, to form coherent mass, which is passed through mesh and dried. The dried granules are mixed with extra granulating agents and allergen in added to the granules and further allowed for drying. Finally, the dried granules are subjected to lubrication and compression. The tablets exhibited high absorption rate and use of lyophilized bioactive ingredients makes the formulation highly stable.
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