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IL1RAP EXPRESSION ON ACUTE AND CHRONIC MYELOID LEUKEMIA CELLS.
IL1RAP EXPRESSION ON ACUTE AND CHRONIC MYELOID LEUKEMIA CELLS.
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机译:IL1RAP在急性和慢性髓性白血病细胞中的表达。
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摘要
The present invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in inducing cell death and/or inhibiting the growth and/or proliferation of pathological stem cells and/or progenitor cells associated with a neoplastic hematologic disorder, wherein the cells express IL1RAP. A related aspect of the invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for use in detecting pathological stem cells and/or progenitor cells associated with a neoplastic hematologic disorder, wherein the cells express IL1RAP. Further provided are pharmacological compositions comprising the agents of the invention and methods of using the same.
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