Genetically modified, recombinant fibroblast growth factor (FGF1) conjugated with nanoparticles of metal or metal oxide, its DNA and amino acid sequence and the use thereof

摘要

The object of the invention is to provide a genetically modified recombinant fibroblast growth factor 1 (FGF1) characterised in that it contains Cys-to-Ser mutation at position (117) in amino acid sequence shown as SEQ ID NO: 1 or SEQ ID NO: 3, and which has decreased aggregation properties in conjugate with metal or metal oxide nanoparticle, preferably gold nanoparticle. The next object of the invention is to provide a conjugate of metal or metal oxide nanoparticles (preferably gold nanoparticles) with the said polypeptide, and its use in induction of hyperthermia caused by exposition of conjugate to near infrared (NIR) light.