首页> 外国专利> COMPOSITION FOR DIFFERENTIATING NON-DENTAL MESENCHYMAL STEM CELLS INTO ODONTOBLASTS, CONTAINING CPNE7 PROTEIN, AND DIFFERENTIATION METHOD USING SAME, AND PHARMACEUTICAL COMPOSITION FOR REGENERATING PULP TISSUE AND TREATING DENTIN HYPERESTHESIA, USING SAME

COMPOSITION FOR DIFFERENTIATING NON-DENTAL MESENCHYMAL STEM CELLS INTO ODONTOBLASTS, CONTAINING CPNE7 PROTEIN, AND DIFFERENTIATION METHOD USING SAME, AND PHARMACEUTICAL COMPOSITION FOR REGENERATING PULP TISSUE AND TREATING DENTIN HYPERESTHESIA, USING SAME

机译：用于将非牙齿间充质干细胞分化为包含CPNE7蛋白的成牙本质母细胞的组合物，以及使用相同的分化方法以及用于重建牙髓组织和治疗牙本质充血的药物组合物

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摘要

The present invention relates to: a composition for differentiating non-dental mesenchymal stem cells into odontoblasts, containing CPNE7 protein; a method for differentiating in vitro non-dental mesenchymal stem cells by using the composition; and a use thereof.

机译：本发明涉及一种含有CPNE7蛋白的非牙齿间充质干细胞分化为成牙本质细胞的组合物。通过该组合物分化体外非牙齿间充质干细胞的方法;及其用途。 展开▼

著录项

公开/公告号WO2015194753A1

专利类型

公开/公告日2015-12-23

原文格式PDF

申请/专利权人 SNU R&DB FOUNDATION;
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申请/专利号WO2015KR04085

发明设计人 PARK JOO-CHEOL;CHOUNG HAN-WOOL;
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申请日2015-04-24

分类号C12N5/071;C07K14/47;C12N15/11;A61K35/12;

国家 WO

入库时间 2022-08-21 14:19:56

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1. ROR1阳性的间充质干细胞及其制备方法、包含ROR1阳性的间充质干细胞的药物组合物及其制备方法、以及使用ROR1阳性的间充质干细胞的疾病的预防或治疗方法 [P] . 中国专利： CN108350427A . 2018-07-31

2. 表达选自由CD201、CD46、CD56、CD147和CD165组成的组中的至少1种细胞表面标记物的间充质干细胞及其制备方法、以及包含上述间充质干细胞的药物组合物及其制备方法 [P] . 中国专利： CN109104869A . 2018-12-28

3. CPNE7 Method and Composition for differentiation of non-dental mesenchymal stem cell into odontoblast using CPNE7 or its gene and pharmaceutical composition for dentin or pulp regeneration or treating dentin hyperesthesia using the same [P] . 韩国专利： KR101627917B1 . 2016-06-07

机译： CPNE7使用CPNE7或其基因将非牙齿间充质干细胞分化为成牙本质细胞的方法和组合物以及用于牙本质或牙髓再生或使用其治疗牙本质增生的药物组合物

4. METHOD AND COMPOSITION FOR DIFFERENTIATION OF NON-DENTAL MESENCHYMAL STEM CELL INTO ODONTOBLAST USING CPNE7 OR ITS GENE AND PHARMACEUTICAL COMPOSITION FOR DENTIN OR PULP REGENERATION OR TREATING DENTIN HYPERESTHESIA USING THE SAME [P] . 韩国专利： KR20150145470A . 2015-12-30

机译：使用CPNE7或其基因将非牙齿间充质干细胞分化为牙本质细胞的方法和组合物以及用于牙本质或牙髓再生或治疗牙本质过敏的药物组合物

5. Method and composition for differentiation of non-dental mesenchymal stem cells containing CPNE7 protein into odontoblasts, and pharmaceutical composition for treatment of dental pulp tissue and treatment of hypersensitivity to dentin using the same [P] . 日本专利： JP2017519505A . 2017-07-20

机译：用于将含有CPNE7蛋白的非牙齿间充质干细胞分化为成牙本质细胞的方法和组合物，以及用于治疗牙髓组织和使用其治疗牙本质过敏的药物组合物

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2. Induction of Differentiation of Mesenchymal Stem Cells into Retinal Pigment Epithelial Cells for Retinal Regeneration by Using Ciliary Neurotrophic Factor in Diabetic Rats [J] . Qing HUANG, Yi DING, Ji-guo YU, 当代医学科学(英文) . 2021,第001期

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4. Potential Role of Dentin Sialoprotein by Inducing Dental Pulp Mesenchymal Stem Cell Differentiation and Mineralization for Dental Tissue Repair [J] . Dental Hypotheses . 2010,第2期

5. Improved accumulation of TGF-beta by photopolymerized chitosan/silk protein bio-hydrogel matrix to improve differentiations of mesenchymal stem cells in articular cartilage tissue regeneration (vol 203, pg 1, 2020) [J] . Shao Jiahua, Ding Zheru, Li Lexiang, Journal of Photochemistry and Photobiology, B. Biology: Official Journal of the European Society for Photobiology . 2020,第1期

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8. Potential Role of Dentin Sialoprotein by Inducing Dental Pulp Mesenchymal Stem Cell Differentiation and Mineralization for Dental Tissue Repair [O] . Guo-Hua Yuan, Guo-Bin Yang, Li-An Wu, -1

9. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - 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V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

10. Methods and Compositions Relating to Neuronal Cell and Tissue Differentiation. [R] . Macklis, J. D., Arlotta, P., Molyneaux, B. J. 2005

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