HUMAN SKIN MODEL AN USE THEREOF FOR EVALUATING EX VIVO THE DERMATOLOGICAL, COSMETIC AND/OR NUTRACEUTICAL EFFECTS OF COMPOUNDS

摘要

The invention relates to a human skin model which maintains, ex vivo, histological integrity and biological functionality of the skin, comprising in combination a sample of human skin between 5 and 10 mm in size and consisting of an epidermis (1) and a dermis (2) placed on a support (3) having, at the level of the porous base thereof (4), the same size as the skin sample, the dermis (2) of the skin sample and the base of the support (4) bathing in a container (6) comprising a culture medium (5) which is renewed every one to three days. The invention also relates to the use of the human skin model for evaluating ex vivo compounds or formulations of interest, to a method for modelling and analyzing a selected treatment of human skin and to the use of a sample of human skin ex vivo for analyzing a selected treatment of the skin.