DIPEPTIDYL PEPTIDASE-IV(DPP4) INHIBITORS, METHODS AND COMPOSITIONS FOR SUPPRESSING ADIPOSE TISSUE INFLAMMATION

摘要

The invention relates generally to blocking dipeptidyl-peptidase 4 (DPP4) secretion/synthesis in hepatic cells, which in turn inhibits or blocks adipose tissue inflammation. This process is involved in metabolism and type 2 diabetes, and will be useful for developing new DPP4 inhibitors and for treating or preventing conditions such as type 2 diabetes, metabolic syndrome, obesity, insulin resistance, as well as pre diabetes, diabetic retinopathy, diabetic neuropathy, diabetic nephropathy, diabetic dyslipidemia, fatty liver disease including non-alcoholic fatly liver disease (NASH), and atherosclerosis.