Thermal Protodeboronation of hydroxyarene Boronic Acids and Its Application to ortho- and meta- Functionalization of hydroxyarene Using Boronic Acids as Blocking and Directing Groups

摘要

the invention hydroxy-arene boronic acid compounds of the thermal de-boron hydride used in the relates to a method of producing a hydroxy-arene was introduced to a group in the ortho or meta position of the phenol-based compounds, and more particularly after the ortho or para position of the phenol was replaced by a boronic acid, climb functional groups in small or meta-position introducing to produce a hydroxy-arene boronic acid compound, and using a thermal de-borohydride relates to a process for preparing a hydroxy-arene compound is a functional group introduced in the ortho or meta-position from the phenol by removing the boric acid. Method of producing a hydroxy-arene compound according to the present invention does not require a metal catalyst such as palladium or iridium and a strong acid or base conditions, low-temperature reaction, and does not require a difficult process, such as reaction with an anhydrous condition economical, It can be prepared simply hydroxy arene compound was introduced to a group in the ortho or meta position phenol. ;