DIAMINOPYRIMIDINE P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR TREATMENT OF ACUTE, SUB-ACUTE OR CHRONIC COUGH

摘要

The present invention relates to a method of treating a disease associated with a P2X receptor, comprising administering a diaminopyrimidine compound having an activity as an antagonist of P2X purinergic receptor and an effective amount of a diaminopyrimidine compound. More particularly, the method is provided for using P2X3 and / or P2X2 / 3 antagonists in the treatment of cough, chronic cough, and coughing impulses in respiratory conditions and disorders.