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GALECTIN-1 SECRETED FROM MESENCHYMAL STEM CELLS MODULATES EXTRACELLULAR -SYNUCLEIN BY INHIBITING TRANSMISSION VIA CLATHRIN-MEDIATED ENDOCYTOSIS
GALECTIN-1 SECRETED FROM MESENCHYMAL STEM CELLS MODULATES EXTRACELLULAR -SYNUCLEIN BY INHIBITING TRANSMISSION VIA CLATHRIN-MEDIATED ENDOCYTOSIS
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机译:通过间质干细胞介导的内分泌抑制,从间充质干细胞分泌的半乳凝素-1调节细胞外突触核蛋白的表达。
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摘要
The present invention relates to a method for treating Parkinsons disease associated with aggregation of alpha-synuclein. More specifically, regulation of N-methyl-D-aspartate (NMDA) receptors on a cell surface using galectin-1 derived from mesenchymal stem cells brings inhibition of clathrin-mediated endocytosis (CME) of extracellular alpha-synuclein, thereby blocking formation of alpha-synuclein aggregates. Thus, it is possible to treat or prevent disease such as Parkinsons disease induced by alpha-synuclein aggregation.
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