METHOD FOR PREDICTING TACROLIMUS BLOOD DRUG CONCENTRATION USING BASE SEQUENCE POLYMORPHISM IN CYP3A5 AND CYP3A7 GENE PARTS

摘要

The present invention relates to a method for predicting a drug concentration of an entity with respect to tacrolimus. More specifically, the present invention relates to a composition for predicting a drug concentration of an entity with respect to tacrolimus, wherein the composition comprises rs10211, rs12360, and rs2257401 disposed in CYP3A7 and rs15524 single nucleotide polymorphism (SNP) disposed in CYP3A5; a kit for detecting the SNP; and a method for predicting a drug concentration of an entity with respect to tacrolimus by analyzing a haplotype with respect to the SNP. According to the present invention, the composition preliminarily predicts a drug concentration of an entity with respect to tacrolimus according to a genetic difference of an entity, so the composition may be useful in determining a suitable administration amount of tacrolimus. Thus, in the early stage, a drug concentration in blood may be made to rapidly reach a proper treatment region, so early repulsion and occurrence of drug side effects are reduced. Consequently, the composition is very useful in ensuring effectiveness and safety of tacrolimus.;COPYRIGHT KIPO 2016