首页> 外国专利> POLYVALENT IMMUNIZING AND / OR THERAPEUTIC COMPOSITION FOR USE IN BACTERIAL INFECTIONS OR FOOD POISONING, IN PARTICULAR SALMONELLOSIS, METHOD OF OBTAINING THIS COMMUNITY COMMUNITY,

POLYVALENT IMMUNIZING AND / OR THERAPEUTIC COMPOSITION FOR USE IN BACTERIAL INFECTIONS OR FOOD POISONING, IN PARTICULAR SALMONELLOSIS, METHOD OF OBTAINING THIS COMMUNITY COMMUNITY,

机译:用于特别是沙门氏菌病的细菌感染或食物中毒的多价免疫和/或治疗组合物,用于获得该社区的方法,

摘要

1. A multivalent combined immunizing and / or anti-salmonellosis therapeutic composition comprising an inactivated Salmonella sp. Strain to which antibodies are linked, characterized in that the antibodies are selected so as to bind antigenic epitopes in the structures of repeating O-specific units in the main Salmonella bacteria groups that determine the principle of interaction with the host immune system, without blocking the epitopes that determine the recognition of the Salmonella serotype. 2. A composition according to claim 1, containing inactivated bacteria of the species enterica of the genus Salmonella: enterica, salamae, arizonae and / or diarizonae, houtenae and Indica. 3. The composition according to PP. 1 or 2, characterized in that the inactivated bacteria of the genus Salmonella belong to at least one of the following subgroups: from group 4 (B), in particular, serovars: Salmonella Typhimurium, Salmonella Typhimurium (for example, 1,4, [5], 12: i: -), Salmonella Agona, Salmonella Bredeney, Salmonella Heidelberg, Salmonella Indiana, Salmonella Saintpaul, Salmonella Brandenburg, Salmonella Agama, Salmonella Derby, Salmonella Stanley, Salmonella Paratyphi B, Salmonella Schleissheim, Salmonella Chester; from groups 6.7 and 8, (C1-C3), in particular, serovars: Salmonella Paratyphi C, Salmonella Infantis, Salmonella Hadar, Salmonella Mbandaka, Salmonella Livingstone, Salmonella Virchow, Salmonella Ohio, Salmonella Montevideo, Salmonella Tennessee, Salmonella Rissen, Salmonella Bareienburg, Salmonella Thompson, Sal monella Newport, Salmonella Kottbus, Salmonella Kentucky, Salmonella Albany, Salmonella Bovismorbificans, Salmonella Djugu, Salmonella Breanderup, Salmonella Jeruzalem, Salmonella Chester, Salmonella Goldcoast, Salmonella Braenderup; from groups 9 and 9.46 (D1-D2), in particular, serovars : Salmonella Enteritidis, Salmonella Panama, Salmonella Dublin, Salmonella Gallinarum, Salmonella Miami, Salmonella Sendai, Salmonella Wernigerode, Salmonella Typhi; from the group 3,10 [,] and 1,3,19 (E1-E4), in particular, serovars: Salmonella Give, Salmonella Anatum, Salmonella London, Salmonella Meleagridis, Salmonella Cambridge, Salmonella Minneapolis, Salmonella Simsbury, Salmonella Senftenberg, Salmonella Westerstede; from group 11 (F), in particular Salmonella Aberdeen; from group 13 (G1-G2), in particular , serovars: Salmonella Cubana, Salmonella Poona; from group 6.14 (H), in particular, serovars: Salm onella Heves, Salmonella Onderstepoort; from group 16 (I), in particular, serovars: Salmonella Brazil, Salmonella Hvittingfoss; from group 17 (J), in particular, Salmonella Berlin serovar; from group 18 (K), in particular, Salmonella serovar Ilia (O: 18); and from additional subgroups numbered 21, 28, 30, 35, 38, 39, 40, 41, 42, 43, 44, 45, 47, 48, and 50.4. The composition according to PP. 1 or 2, characterized in that the antibodies are isolated from rabbit serum immunized with Salmonella antigens. 5. The composition according to PP. 1 or 2, characterized in that said antibodies are isolated from the yolk of poultry eggs, in particular chicken eggs obtained from a bird immunized with Salmonella antigens. 6.
机译:1.一种多价组合的免疫和/或抗沙门氏菌病治疗组合物,其包含灭活的沙门氏菌。与抗体相连的菌株,其特征在于选择抗体以结合沙门氏菌主要细菌群中重复O特异性单元结构中的抗原表位,这些结构决定了与宿主免疫系统相互作用的原理,而不会阻断决定沙门氏菌血清型识别的抗原决定簇。 2.根据权利要求1的组合物,其包含沙门氏菌属肠杆菌物种的灭活细菌:肠杆菌,萨拉马,亚利桑那和/或双链杆菌,小菜蛾和In。 3.根据PP的组成。 1或2,其特征在于沙门氏菌属的灭活细菌至少属于以下亚组之一:来自组4(B),特别是血清型:鼠伤寒沙门氏菌,鼠伤寒沙门氏菌(例如1,4,[ 5],12:i:-),沙门氏菌Agona,沙门氏菌布列塔尼,沙门氏菌海德堡,沙门氏菌印第安那,沙门氏菌Saintpaul,沙门氏菌勃兰登堡,沙门氏菌Agama,沙门氏菌Derby,沙门氏菌Stanley,沙门氏菌副伤寒B,沙门氏菌Schleissheim,沙门氏菌切斯特;来自6.7和8组(C1-C3),特别是血清型:沙门氏菌C,沙门氏菌Infantis,沙门氏菌Hadar,沙门氏菌Mbandaka,沙门氏菌Livingstone,沙门氏菌Virchow,俄亥俄沙门氏菌,沙门氏菌Montevideo,沙门氏菌田纳西州,沙门氏菌立森,沙门氏菌,沙门氏菌汤普森(Salmonella Thompson),沙门氏菌纽波特(Sal monella Newport),沙门氏菌Kottbus,肯塔基州沙门氏菌,沙门氏菌奥尔巴尼(Salmonella Albany),沙门氏菌Bovismorbificans,沙门氏菌Djugu,沙门氏菌Breanderup,沙门氏菌Jeruzalem,沙门氏菌Chester,沙门氏菌Goldcoast,沙门氏菌Braenderup;来自第9和9.46组(D1-D2),尤其是血清型:沙门氏菌,巴拿马沙门氏菌,都柏林沙门氏菌,沙门氏菌Gallinarum,迈阿密沙门氏菌,仙台沙门氏菌,韦尔尼格罗德沙门氏菌,伤寒沙门氏菌;从3,10 [,]和1,3,19(E1-E4)组中选取,尤其是血清型:沙门氏菌给,沙门氏菌,伦敦沙门氏菌,Meleagridis沙门氏菌,剑桥沙门氏菌,明尼阿波利斯沙门氏菌,Simsbury沙门氏菌,Senmonenberg沙门氏菌,沙门氏菌Westerstede;来自第11(F)组,尤其是沙门氏菌;来自第13组(G1-G2),尤其是血清型:古巴沙门氏菌,沙门氏菌Poona;来自6.14(H)族,特别是血清型:沙门氏菌Heves,沙门氏菌Onderstepoort;来自第16(I)组的病毒,特别是血清型:巴西沙门氏菌,沙门氏菌Hvittingfoss;来自第17(J)组,特别是柏林沙门氏菌血清型;来自第18组(K),特别是沙门氏菌血清伊利亚(O:18);以及来自其他子组的21、28、30、35、38、39、40、41、42、43、44、45、47、48和50.4。根据PP的组成。 1或2,其特征在于从沙门氏菌抗原免疫的兔血清中分离抗体。 5.根据PP的组成。 1或2,其特征在于所述抗体是从禽蛋卵黄中分离的,特别是从用沙门氏菌抗原免疫的禽类获得的鸡蛋。 6。

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