METHOD FOR OBTAINING TREPEPTIDE OF GENERAL FORMULA (I) HPyr-His-TrpOH, APPLIED AS INTERMEDIATE COMPOUND (1-3 FRAGMENT) IN SYNTHESIS OF SYNTHETIC AGONISTS OF GONADOTROPIN-RELEASING-HORMONE (LH-RH), BY METHOD OF LIQUID-PHASE PEPTIDE SYNTHESIS WITHOUT PLACING AND REMOVAL OF PROTECTIVE GROUPS

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to method of obtaining HPyr-His-TrpOH applied as main semi-product (1-3 fragment) in synthesis of synthetic antagonists of gonadotropine-releasing-hormone, LH-RH. Tripeptide (I) is obtained by method of liquid-phase peptide synthesis without application of stages of placement and removal of protective groups.;EFFECT: method makes it possible to reduce quantity of synthesis stages, is more economically effective due to absence of placement and removal of protective groups stages and makes it possible to obtain tripeptide with high purity.;1 ex