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T-CELL RECEPTOR CLONOTYPES SHARED AMONG ANKYLOSING SPONDYLITIS PATIENTS
T-CELL RECEPTOR CLONOTYPES SHARED AMONG ANKYLOSING SPONDYLITIS PATIENTS
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机译:在强直性脊柱炎患者中共有T细胞受体基因型
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摘要
The invention includes a method for determining the disease status of an individual suffering from ankylosing spondylitis by monitoring the individual's T-cell repertoire for the presence and/or level of clonotypes encoding T-cell receptor chains with segments identical to and/or related to the peptide LCASSLEASGSSYNEQFFGPGTRLTV (SEQ ID NO: 1) or the peptide VYFCASSDSSGSTDTQYFGPGTRLTV (SEQ ID NO: 2). The invention also includes therapeutic antibodies specific for these peptides for ameliorating the effects of ankylosing spondylitis.
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机译:本发明包括一种通过监测个体的T细胞库中编码T细胞受体链的克隆型的存在和/或水平来确定患有强直性脊柱炎的个体的疾病状态的方法,所述克隆的类型与所述T细胞受体链相同和/或相关。肽LCASSLEASGSSYNEQFFGPGTRLTV(SEQ ID NO:1)或肽VYFCASSDSSGSTDTQYFGPGTRLTV(SEQ ID NO:2)。本发明还包括对这些肽具有特异性的治疗性抗体,以改善强直性脊柱炎的作用。
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