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POLARIZATION OF MACROPHAGES TO A HEALING PHENOTYPE BY CARDIOSPHERE-DERIVED CELLS AND BY THE EXOSOMES SECRETED BY SUCH CELLS
POLARIZATION OF MACROPHAGES TO A HEALING PHENOTYPE BY CARDIOSPHERE-DERIVED CELLS AND BY THE EXOSOMES SECRETED BY SUCH CELLS
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机译:心球来源的细胞和此类细胞分泌的外显子组将巨噬细胞极化成愈合表型
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摘要
Described herein are compositions and techniques related to generation and therapeutic application of stem cell-derived exosomes. The Inventors have discovered cardiosphere-derived cells (CDCs) and their secreted exosomes mediate such inflammatory processes, by, for example, shifting macrophages away from a proinflammatory M1 phenotype toward M2 healing phenotype. This suggests compositions and techniques for use in both long-term reversal of heart and vascular disease pathology, and protection against such disease progression via modulation of inflammation and immune responses.
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